What Are Ondansetron And Metoclopramide
Ondansetron is an anti-nausea medication used to prevent nausea and vomiting that results from cancer chemotherapy. Chemotherapy agents cause increased secretion of serotonin, which stimulates serotonin receptors in the brain, resulting in nausea and vomiting. Ondansetron works by selectively blocking serotonin receptors, thereby reducing the effect of increased serotonin due to chemotherapy. It is also prescribed for prevention of nausea and vomiting after surgery.
Metoclopramide is a prokinetic drug that stimulates the muscles of the gastrointestinal tract including the muscles of the lower esophageal sphincter, stomach, and small intestine by interacting with receptors for acetylcholine and dopamine on gastrointestinal muscles and nerves. It is used in adults to relieve heartburn symptoms with gastroesophageal reflux when certain other treatments do not work and to relieve the symptoms of slow stomach emptying in people with diabetes.
Why Treat Heartburn And Acid Reflux During Pregnancy
Heartburn and acid reflux are traditionally considered innocuous because they are common in pregnancy and are usually self-limiting. However, a recent study suggests that GERD is associated with an increase in the severity of nausea and vomiting of pregnancy , which can have serious negative effects on a womans quality of life. In a prospective cohort study conducted by the Motherisk Program, 194 pregnant women with NVP and heartburn or acid reflux were compared with 188 pregnant women with NVP who did not have heartburn or acid reflux. The 2 groups were assessed for severity of NVP with the pregnancy-unique quantification of emesis and nausea score, which is a validated scoring tool based on frequency and duration of nausea, vomiting, and retching in the past 24 hours, with a high score indicating more severe NVP. Quality of life was measured by the well-being score, with 0 being the worst and 10 being the best. Forty-eight percent of women in the control group had severe NVP according to the PUQE, compared with 75% in the group with heartburn and acid reflux. The mean well-being score in the control group was significantly higher than that in the group with heartburn and acid reflux .
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Be Persistent And Be Careful
Most medications work only less than half of the time. Nonetheless, most people will respond to some therapy. If a medication causes side effects, consider a lower dose. If it doesnt work, try something else. Combining medications may be helpful. The effectiveness of various agents differs between individuals. Importantly, a medication regimen must be carefully chosen under the direction of the physician. Keep hydrated and as nutritionally fit as possible.
When treatment is failing and there appear to be no other options whether you are the patient or the physician get another opinion. Persistence pays off, as most people with gastroparesis ultimately will do well.
Adapted from IFFGD Publication: Gastroparesis by J. Patrick Waring, MD, Digestive Healthcare of Georgia, Atlanta, GA and William F. Norton, Communications Director, International Foundation for Functional Gastrointestinal Disorders, Milwaukee, WI.
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Do You Feel An Unnecessary Amount Of Pressure On Your Stomach After A Meal Does Your Waistline Seem To Instantly Expand After A Hurried Lunch These Are The Most Common Signs Of Abdominal Bloating Or A Swollen Tummy
- Kriti Malik, NDTV
Do you feel an unnecessary amount of pressure on your stomach after a meal? Does your waistline seem to instantly expand after a hurried lunch? These are the most common signs of abdominal bloating or a swollen tummy.Bloating is a condition where gas released from the breakdown of foods builds up in your stomach and intestines instead of passing out of the body. It can lead to abdominal pain, constipation, digestive disorders etc.This occasional inflation is extremely common and can be cured with some simple diet choices. We asked several researchers to help compile a list of foods that can bring a puffy tummy back to its normal size and this is what they had to say
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How Should I Take Zofran
Take Zofran exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Zofran can be taken with or without food.
The first dose is usually taken before the start of your surgery, chemotherapy, or radiation treatment. Follow your doctor’s dosing instructions very carefully.
Take the regular tablet with a full glass of water.
To take the orally disintegrating tablet :
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Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
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Use dry hands to remove the tablet and place it in your mouth.
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Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
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Swallow several times as the tablet dissolves.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Store at room temperature away from moisture, heat, and light. Store liquid medicine in an upright position.
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Experts Answers For Readers Questions
When should we take a probiotic for bloating?
Probiotics can enhance your gut health. It is better to take it before a meal for it to survive better. The timing isnt a huge factor but it is important to take at the same time each day.
Are probiotics or prebiotics better for bloating?
Prebiotics can cause bloating initially and then settle down whereas probiotics can improve the bacterial environment in our gut, making it reduce gas and bloating.
How long does it take for probiotics to work for bloating?
There can be an improvement in our digestive system within 4 weeks after taking probiotics. There can be minor side effects for the first few days of taking them but it settles down.
B Bloating Without Excess Gas:
You may feel bloated without having excess gas inside your digestive tract. Causes include :
- Functional Gastrointestinal diseases: such as Irritable bowel syndrome, functional dyspepsia, functional bloating, and chronic constipation.
- Abnormal motility of your intestines: as with diabetes, gastroparesis, scleroderma, and others.
- Previous operations, particularly hiatus hernia operations and gastric banding surgery.
- Compression of your intestine from outside by: ovarian tumors, ascites, gastrointestinal malignancy.
- Medications that affect intestinal motility.
- Associated with other gastrointestinal diseases as peptic ulcer disease, h. pylori, and chronic gastritis.
Functional gastrointestinal diseases are widespread. For example, irritable bowel syndrome and functional dyspepsia are two widespread conditions.
Related: what causes bloating after pooping?
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Ondansetron Relieves Irritable Bowel Syndrome Symptoms
Gale ScottInternal Medicine World Report
Patients with irritable bowel syndrome with diarrhea suffer not only the pain and discomfort of frequent loose stools, but fear of incontinence. For many patients, that results in panic and anxiety.
Patients with irritable bowel syndrome with diarrhea suffer not only the pain and discomfort of frequent loose stools, but fear of incontinence. For many patients, that results in panic and anxiety.
In an effort to address those concerns, a team at Nottingham Diseases Centre, University Hospital, Nottingham, UK, conducted a study of ondansetron vs. placebo in a group of 120 IBS-D patients. The group taking ondansetron got significant relief from their debilitating symptoms, Klara Garsed and colleagues reported in Gut .
Compared with placebo, ondansetron significantly improved stool consistency, patients experienced fewer days with urgency, less frequent defecation, and less bloating. Pain associated with IBS-D did not change significantly.
Overall, 65% of patients reported symptom relief with ondansetron, while only 14% getting the placebo reported relief.
In the crossover study, participants received 5 weeks of oral placebo treatment and 5 weeks of ondansetron 4 mg tablets with a 2-3 week washout period in between each treatment period.
Loperamide was allowed as a rescue medication but needed to be discontinued for the final 2 weeks of the period. Patients kept track of their symptoms with daily diaries.
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Can Probiotics Help Bloating
A poor diet encourages less desirable probiotic bacteria to flourish while repressing healthier types. Many times, the candida yeast grows out of control when fed a diet of sugary, processed foods. Replenishing healthy probiotic bacteria can help push back the overgrowth of the Candida.
Adding the right probiotics helps with proper digestion. Many vitamins and minerals are bound in the fibers of food, and the probiotic bacteria break down the fibers to release the nutrients. If they dont, the fibers pass into the large intestine, where bacteria, like E coli, break them down and release methane and hydrogen sulfide as by-products.
Think about the last time you ate beans. They are full of fibers, and some of you get really gassy. With the right probiotics, you wont get so gassy.
Additionally, probiotic bacteria can also help break down sugars, proteins, and fibers that cause intolerances and allergies. Some studies show that probiotic supplementation can even help reduce the effect of the gluten protein in people who have celiac disease.
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What Is The Best Time To Take Probiotics
While it doesnt necessarily matter what time of day you take a probiotic, its probably a good idea to give yourself some time to adjust before going to bed.
Taking a probiotic supplement just before bed is not advised because your body needs some time to rest and recover from the day. This will allow the beneficial bacteria in your supplement to have enough time to reach a high presence in your gut without being slowed down by other body processes.
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How Should I Give It
Ondansetron may be given by mouth as a liquid, pill, or tablet or in a vein . It may be given in one of these ways:
- at regular times
- continuously through an IV
Your child should be awake and alert when taking any medicine by mouth. Follow the checked instructions below:
___ If using the liquid form, draw up the correct amount in the medicine dropper or oral syringe. Give a small squirt of the medicine inside the cheek. To avoid choking, let your child swallow each squirt before giving more.
___ For babies, you may want to mix the medicine with a small amount of formula or breast milk and give it with a bottle nipple before feeding. Do not add the medicine to a whole bottle because if your baby does not finish it, you will not know how much of the medicine was taken.
___ For older children who cannot swallow pills, a special tablet called Zofran ODT is available. Place it under the tongue and it will dissolve.
Other instructions:
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People Of Asian Descent
People of Asian descent have an increased risk of dementia from proton pump inhibitors such as omeprazole. Compared to other populations, a higher percentage of Asians metabolize omeprazole very slowly20% compared to around 3%. The prescribing information for omeprazole recommends a lower dose in these patients.
Ondansetron For Irritable Bowel Syndrome
A recent trial indicates that the antinausea medication ondansetron may have some utility in treating the symptoms of diarrhea-associated irritable bowel syndrome.
A recent trial indicates that the antinausea medication ondansetron may have some utility in treating the symptoms of diarrhea-associated irritable bowel syndrome.
Investigators at the University of Nottingham and associated hospitals in the United Kingdom found that ondansetron improved stool consistency and several markers of diarrhea-associated irritable bowel syndrome symptoms compared with placebo.
In the trial, all patients had IBS-D as defined by the Rome III criteria. After a 2- to 3-week washout period in which patients did not take medication for IBS, investigators randomized 120 patients to each treatment group in an approximately 1:1 ratio. Patients then received 5 weeks of treatment with ondansetron or placebo and recorded bowel symptoms in a diary. Over the first 3 weeks, patients were instructed to increase the dose slowly to a maximum total daily dose of 24 mg . Despite these instructions, the median dose of ondansetron used in the trial was 4 mg daily.
Ondansetron works by blocking a subtype of serotonin receptors associated with nausea . Blocking this serotonin receptor may also reduce the serotonergic signaling that induces symptoms of loose stool and bowel urgency in patients with IBS.
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What Are The Side Effects Of Activia Yogurt
Activia yogurt contains probiotics. When you first start taking probiotics, its common to have side effects, such as gas, bloating, mild stomach upset, or diarrhea. These problems usually resolve with continued use as your body gets used to the probiotics.
Activia is a probiotic yogurt that may help reduce the frequency of minor digestive discomfort when consumed twice a day for two weeks as part of a balanced diet and healthy lifestyle. Minor digestive discomfort includes bloating, gas, abdominal discomfort, and rumbling.
Beside this, What is the best time to eat Activia yogurt?
Among those four, it turns out that the best option to consume yogurt is during breakfast or on an empty stomach. This is because good bacteria or probiotics in yogurt must arrive at the large intestine in a live condition to effectively maintain digestion and health.
Likewise, Is it OK to eat probiotic yogurt every day?
The Bottom Line Yogurt is rich in nutrients and may boost your health when consumed regularly. It may help reduce the risk of some diseases, while also benefiting digestive health and weight control. However, make sure to choose your yogurt wisely.
Also, How many probiotic yogurts can I eat a day?
How much is enough? Usually, we recommend one serving of yogurt in order to get your daily dose of healthy bacteria.
Is Activia yogurt bad for you?
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Does Zofran Calm You Down
Ondansetron showed greater therapeutic efficacy at alleviating symptoms of overall mood disturbance, fatigue, vigor, confusion/bewilderment, and depression among EOA compared with LOA. EOA-associated improvements in mood disturbance seemed to be independent of drinking behavior.
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Does Omeprazole Help With Gas And Bloating Gastroenterologist Explains
Our content is not intended nor recommended as a substitute for medical advice by your doctor. Use for informational purposes only.
Omeprazole isnt anti-gas medicine. It acts as an acid-reducing drug. Whether omeprazole works for gas and bloating depends on the cause of bloating.
Omeprazole doesnt help with excess gas inside your digestive tract. But it can help with bloating associated with functional dyspepsia, peptic ulcer disease, functional bloating, and IBS.
For Nausea And Vomiting
Last nights Chinese take-out leftovers seem like a great meal ideauntil your stomach clearly begins to disagree with you. Nausea and vomiting are one of your bodys major defenses against food poisoning, and can also arise from problems like motion sickness and overeating. While the best way to cure an upset stomach from most cases of food poisoning is to let your body rid itself of the bacteria causing your discomfort, over-the-counter antiemetics can come in handy when dealing with nausea and vomiting symptoms caused by motion sickness and certain other conditions. There are two main types of OTC medications used to treat nausea and vomiting:
- Bismuth subsalicylate, the active ingredient in OTC medications like Kaopectate® and Pepto-Bismol, protects your stomach lining. Bismuth subsalicylate is also used to treat ulcers, upset stomach and diarrhea.
- Other medicines include cyclizine, dimenhydrinate, diphenhydramine, and meclizine. These can be found in medicines such as Dramamine, Bonine, or others, and they dull motion sickness by acting on your brain. They block messages from reaching the part of the brain that controls nausea and vomiting
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What Other Drugs Will Affect Ondansetron
Ondansetron can cause a serious heart problem, especially if you use certain medicines at the same time, including antibiotics, antidepressants, heart rhythm medicine, antipsychotic medicines, and medicines to treat cancer, malaria, HIV or AIDS. Tell your doctor about all medicines you use, and those you start or stop using during your treatment with ondansetron.
Receiving ondansetron while you are using certain other medicines can cause high levels of serotonin to build up in your body, a condition called “serotonin syndrome,” which can be fatal. Tell your doctor if you also use:
- medicine to treat depression
- medicine to treat a psychiatric disorder
- a narcotic medication or
- medicine to prevent nausea and vomiting.
This list is not complete and many other drugs can interact with ondansetron. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
What Should I Discuss With My Healthcare Provider Before Receiving Ondansetron
You should not use this medicine if you are allergic to ondansetron, or if you are also using apomorphine .
To make sure ondansetron is safe for you, tell your doctor if you have:
- heart disease, congestive heart failure, a heart rhythm disorder
- an electrolyte imbalance
- a personal or family history of Long QT syndrome or
- a condition for which you take a diuretic or “water pill.”
Ondansetron is not expected to harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether ondansetron passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
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Causes And Risk Factors
There are several risk factors that are considered to play a role in the conditions cause, such as vagus-nerve damage. The vagus nerve is the longest cranial nerve in the body and is responsible for many functions. It is especially essential for proper operation of the digestive tract. If the vagus nerve is damaged, transfer of food from the abdomen to the small intestine is reduced because the muscles will not operate properly.4
Type 1 and type 2 diabetes are known to damage the vagus nerve. Some autoimmune diseases and virus infections are also believed to have a negative impact on the vagus nerve. In certain cases, the vagus nerve stops working properly due to drinking excessive alcohol. Surgical complications could also affect the vagus nerve.4
Other factors that can increase the risk of gastroparesis include abdominal or esophageal surgery, infection , certain medications that slow the rate of stomach emptying , nervous system diseases and hypothyroidism.4 Complications resulting from gastroparesis are shown in TABLE 1.
Sometimes, treating the cause may stop the problem. If diabetes is causing gastroparesis, patients must control their blood glucose levels. Acute hyperglycemia may impair gastric motor function as well as inhibit the action of prokinetic drugs, such as erythromycin. In patients with type 1 diabetes, gastroparesis can be an indication for insulin-pump therapy.5